Appleton is a city in Outagamie, Calumet, and Winnebago counties in the U.S. state of Wisconsin. One of the Fox Cities, it is situated on the Fox River, 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee. Appleton is the county seat of Outagamie County. As of the 2020 Census it had a population of 75,644, making it the sixth largest city in Wisconsin. Appleton is a part of the Fox Cities metropolitan area, the third largest in the state behind Milwaukee and Madison. Appleton serves as the heart of the Fox River Valley and is home to Lawrence University, the Fox Cities Exhibition Center, Fox Cities Performing Arts Center, Fox River Mall, Neuroscience Group Field at Fox Cities Stadium, Appleton International Airport, and the Valley's two major hospitals: St. Elizabeth Hospital and ThedaCare Regional Medical Center–Appleton. It also hosts regional events such as Octoberfest and the Mile of Music.