Appleton (Menominee: Ahkōnemeh) is the county seat of Outagamie County, Wisconsin, United States, with small portions extending into Calumet and Winnebago counties. Located on the Fox River, it lies 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee. The city had a population of 75,644 at the 2020 census, making it the sixth-most populous city in Wisconsin, while the Appleton metropolitan statistical area had 243,147 residents. Appleton is part of the broader Fox Cities region. Appleton serves as the heart of the Fox River Valley, which is home to Lawrence University, the Fox Cities Exhibition Center, Fox Cities Performing Arts Center, Fox River Mall, Neuroscience Group Field at Fox Cities Stadium, Appleton International Airport, and the Valley's two major hospitals: St. Elizabeth Hospital and ThedaCare Regional Medical Center–Appleton. It also hosts regional events such as Octoberfest and the Mile of Music.