Sanford is a city in the central region of the U.S. state of Florida and the county seat of Seminole County. As of the 2010 census, its population was 53,570.
Known as the "Historic Waterfront Gateway City," Sanford sits on the southern shore of Lake Monroe at the head of navigation on the St. Johns River. Native Americans first settled the area thousands of years before the city was formed. The Seminoles arrived in the area in the 18th century. During the Second Seminole War in 1836, the United States Army established Camp Monroe and built a road now known as Mellonville Avenue. Sanford is about 20 miles (32 km) northeast of Orlando.
Sanford is home to Seminole State College of Florida and the Central Florida Zoo and Botanical Gardens. Its downtown attracts tourists with shops, restaurants, a marina, and a lakefront walking trail. The Orlando Sanford International Airport, in the heart of the town, functions as the secondary commercial airport for international and domestic carriers in the Orlando metropolitan area.